Factors influencing early and late mortality in adults with invasive pneumococcal disease in Calgary, Canada: a prospective surveillance study.

Leah J Ricketson
Alberto Nettel-Aguirre
Otto G Vanderkooi
Kevin B Laupland
James D Kellner

Open link

DOI

10.1371/journal.pone.0071924

Publisher

Public Library of Science (PLoS)

Journal

issn:1932-6203

Abstract

BACKGROUND: Invasive pneumococcal disease continues to be an important cause of mortality. In Calgary, 60% of deaths occur within 5 days of presenting to hospital. This proportion has not changed since before the era of penicillin. The purpose of this study was to investigate what factors may influence death within 5 days of presentation with pneumococcal disease. METHODS AND FINDINGS: Demographic and clinical data from the CASPER (Calgary Area Streptococcus pneumoniae Epidemiology Research) study on 1065 episodes of invasive pneumococcal disease in adults (≥18 years) from 2000 to 2010 were analyzed. Adjusted multinomial regression was performed to analyze 3 outcomes: early mortality (<5 days post-presentation), late mortality (5-30 days po...