The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian pancreas, liver, kidney and gut. The layout of this network appears to be similar in rodents and humans, but inactivation of HNF1A, HNF1B or HNF4A genes in animal models cause divergent phenotypes to those seen in man. We hypothesised that some differences may arise from variation in the expression profile of alternatively processed isoforms between species.We measured the expression of the major isoforms of the HNF1A, HNF1B and HNF4A genes in human and rodent pancreas, islet, liver and kidney by isoform-specific quantitative real-time PCR and compared their expression by the comparative Ct (DeltaDeltaCt) method. We found major changes in the expression prof...
<p>A, mRNA expression level in human pancreatic cancer cell lines relative to control cell line COLO...
The orphan hepatic nuclear factor (HNF) HNF4 is of pivotal importance for liver development and hep...
Nuclear receptors (NRs) are ligand-sensitive transcription factors that regulate a wide array of bio...
BACKGROUND: The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian panc...
Background: The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian panc...
<p>The expression profile of the <i>HNF1A</i> gene in human, mouse and rat is given. The species is ...
<p>The expression profile of the <i>HNF1B</i> gene in human, mouse and rat is given. The species and...
OBJECTIVE The evolutionary conservation of transcriptional mechanisms has been widely exploited to u...
The transcription of individual genes is determined by combinatorial interactions between DNA–bindin...
<p>HNF4α isoform expression was measured by real time qRT-PCR in INS-1E ...
Heterozygous mutations in the genes encoding tran-scriptional regulators hepatocyte nuclear factor (...
Heterozygous HNF1A mutations cause pancreatic-islet beta-cell dysfunction and monogenic diabetes (MO...
OBJECTIVE: Mutations in the alternatively spliced HNF4A gene cause maturity-onset diabetes of the yo...
The development of the organism involves the formation of tissues that differ by the morphology and ...
Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor expressed in ...
<p>A, mRNA expression level in human pancreatic cancer cell lines relative to control cell line COLO...
The orphan hepatic nuclear factor (HNF) HNF4 is of pivotal importance for liver development and hep...
Nuclear receptors (NRs) are ligand-sensitive transcription factors that regulate a wide array of bio...
BACKGROUND: The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian panc...
Background: The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian panc...
<p>The expression profile of the <i>HNF1A</i> gene in human, mouse and rat is given. The species is ...
<p>The expression profile of the <i>HNF1B</i> gene in human, mouse and rat is given. The species and...
OBJECTIVE The evolutionary conservation of transcriptional mechanisms has been widely exploited to u...
The transcription of individual genes is determined by combinatorial interactions between DNA–bindin...
<p>HNF4α isoform expression was measured by real time qRT-PCR in INS-1E ...
Heterozygous mutations in the genes encoding tran-scriptional regulators hepatocyte nuclear factor (...
Heterozygous HNF1A mutations cause pancreatic-islet beta-cell dysfunction and monogenic diabetes (MO...
OBJECTIVE: Mutations in the alternatively spliced HNF4A gene cause maturity-onset diabetes of the yo...
The development of the organism involves the formation of tissues that differ by the morphology and ...
Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor expressed in ...
<p>A, mRNA expression level in human pancreatic cancer cell lines relative to control cell line COLO...
The orphan hepatic nuclear factor (HNF) HNF4 is of pivotal importance for liver development and hep...
Nuclear receptors (NRs) are ligand-sensitive transcription factors that regulate a wide array of bio...