Evaluation of Antileishmanial Activity of Albaha Medicinal Plants against Leishmania amazonensis
- Saeed S. Al-Sokari
- Nasser A. Awadh Ali
- Lianet Monzote
- Mohamed A. Al-Fatimi
Publication date
January 2015
DOI Publisher
Hindawi Limited ISSN
2314-6133 Journal
2314-6141 Citation count (estimate)
3Abstract
Sixteen methanolic extracts obtained from thirteen plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antileishmanial activity against Leishmania amazonensis. The cytotoxic activity against normal peritoneal macrophages from normal BALB/c mice was also determined. Eight extracts had IC50 values ranging from <12.5 to 37.8 µg/mL against promastigotes. Achillea biebersteinii flower, Euphorbia helioscopia, and Solanum incanum leaf extracts showed antileishmanial activities with IC50 between <12.5–26.9 µg/mL and acceptable selectivity indices of 8–5. The other leishmanicidal plant extracts, with IC50 ranging from 18.0 to 29.5 µg/mL, exhibited low selectivity indices
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