A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.
- Pieters, Rob
- Schrappe, Martin
- De Lorenzo, Paola
- Hann, Ian
- De Rossi, Giulio
- Felice, Maria
- Hovi, Liisa
- Leblanc, Thierry
- Szczepanski, Tomasz
- Ferster, Alina
- Janka, Gritta
- Rubnitz, Jeffrey
- Silverman, Lewis B
- Stary, Jan
- Campbell, Myriam
- Li, Chi Kong
- Mann, Georg
- Suppiah, Ram
- Biondi, Andrea
- Vora, Ajay
- Valsecchi, Maria Grazia
DOIAbstract
Acute lymphoblastic leukaemia in infants younger than 1 year is rare, and infants with the disease have worse outcomes than do older children. We initiated an international study to investigate the effects of a new hybrid treatment protocol with elements designed to treat both acute lymphoblastic leukaemia and acute myeloid leukaemia, and to identify any prognostic factors for outcome in infants. We also did a randomised trial to establish the value of a late intensification course.Journal ArticleMulticenter StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe
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