Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate II. Ionophoretic and conformational aspects
- Malaisse, Willy
- Bakkali Nadi, Abdellatif
- Malaisse Lagae, Francine
- Sato, Fumiyasatu
- Lins, Laurence
- Brasseur, Robert
DOIAbstract
1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Add to ORKG