Identification of a monoclonal antibody specific for a murine T3 polypeptide.

Leo, Oberdan
Foo, M
Sachs, D H
Samelson, L E
Bluestone, J A

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Publication date

March 1987

DOI

10.1073/pnas.84.5.1374

ISSN

0027-8424

Citation count (estimate)

1003

Abstract

A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.Journal Articleinfo:eu-repo/semantics/publishe