The orphan Leucine-rich repeat G protein-coupled receptor 5 (LGR5/GPR49), a target of Wnt signaling, is a marker of adult intestinal stem cells (SC). However, neither its function in the adults, nor during development of the intestine have been addressed yet. In this report, we investigated the role of LGR5 during ileal development by using LGR5 null/LacZ-NeoR knock-in mice. X-gal staining experiments showed that, after villus morphogenesis, Lgr5 expression becomes restricted to dividing cells clustered in the intervillus region and is more pronounced in the distal small intestine. At day E18.5, LGR5 deficiency leads to premature Paneth cell differentiation in the small intestine without detectable effects on differentiation of other cell l...
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven prolifera...
BACKGROUND & AIMS: Wnt signaling regulates multiple aspects of intestinal physiology, including stem...
SummaryMuch of our understanding about how intestinal stem and progenitor cells are regulated comes ...
AbstractThe orphan Leucine-rich repeat G protein-coupled receptor 5 (LGR5/GPR49), a target of Wnt si...
The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b-catenin signaling...
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently...
LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5) is the most established marker fo...
AbstractLgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs. ...
BACKGROUND: LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5) is the most establish...
Background & Aims: The Lgr family of transmembrane proteins (Lgr4, 5, 6) act as functional receptors...
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally d...
Lgr4 and Lgr5 proteins are known markers of adult and embryonic tissue stem cells in various organs....
Stem cells hold great promise for regenerative medicine, but have remained elusive in many tissues b...
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven prolifera...
Background & AimsThe Lgr family of transmembrane proteins (Lgr4, 5, 6) act as functional receptors f...
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven prolifera...
BACKGROUND & AIMS: Wnt signaling regulates multiple aspects of intestinal physiology, including stem...
SummaryMuch of our understanding about how intestinal stem and progenitor cells are regulated comes ...
AbstractThe orphan Leucine-rich repeat G protein-coupled receptor 5 (LGR5/GPR49), a target of Wnt si...
The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b-catenin signaling...
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently...
LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5) is the most established marker fo...
AbstractLgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs. ...
BACKGROUND: LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5) is the most establish...
Background & Aims: The Lgr family of transmembrane proteins (Lgr4, 5, 6) act as functional receptors...
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We originally d...
Lgr4 and Lgr5 proteins are known markers of adult and embryonic tissue stem cells in various organs....
Stem cells hold great promise for regenerative medicine, but have remained elusive in many tissues b...
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven prolifera...
Background & AimsThe Lgr family of transmembrane proteins (Lgr4, 5, 6) act as functional receptors f...
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven prolifera...
BACKGROUND & AIMS: Wnt signaling regulates multiple aspects of intestinal physiology, including stem...
SummaryMuch of our understanding about how intestinal stem and progenitor cells are regulated comes ...