International audienceRecent analyses of the degradation profiles of thousands of proteins by McShane et al. have shown that many proteins are less stable during the hours following their synthesis. Many of such nonexponentially degraded (NED) proteins are components of macromolecular complexes. This may explain why, in cases of trisomy, the effect of overexpression can be attenuated
Biological aging is often described by its phenotypic effect on individuals. Still, its causes are m...
Aging is a biological and multifactorial process characterized by a progressive and irreversible det...
Proteome and proteostasis network ( disruptions lead to proteostasis imbalances and accumulation of ...
International audienceRecent analyses of the degradation profiles of thousands of proteins by McShan...
Do young and old protein molecules have the same probability to be degraded? We addressed this quest...
Do young and old protein molecules have the same probability to be degraded? We addressed this quest...
Alterations in the rate and extent of protein synthesis, accuracy, posttranslational modifications a...
It has only recently been appreciated that the human body contains many long-lived proteins (LLPs). ...
Aging is a complex process encompassing both genetic and epigenetic modifications leading to the det...
The consequences of improper DNA-maintenance overlap – at least partially – with those of a disrupte...
Changes in the abundance and post-translational modification of proteins and accumulation of some co...
Significance: A constant accumulation of oxidized proteins takes place during aging. Oxidation of pr...
© 2020 The Authors How do cells maintain relative proportions of protein complex components? Advance...
Many Mendelian monogenic disorders are caused by loss of the function of a single protein. This can ...
Aging is a universal phenomenon that is even observed in inorganic material. In the inorganic world ...
Biological aging is often described by its phenotypic effect on individuals. Still, its causes are m...
Aging is a biological and multifactorial process characterized by a progressive and irreversible det...
Proteome and proteostasis network ( disruptions lead to proteostasis imbalances and accumulation of ...
International audienceRecent analyses of the degradation profiles of thousands of proteins by McShan...
Do young and old protein molecules have the same probability to be degraded? We addressed this quest...
Do young and old protein molecules have the same probability to be degraded? We addressed this quest...
Alterations in the rate and extent of protein synthesis, accuracy, posttranslational modifications a...
It has only recently been appreciated that the human body contains many long-lived proteins (LLPs). ...
Aging is a complex process encompassing both genetic and epigenetic modifications leading to the det...
The consequences of improper DNA-maintenance overlap – at least partially – with those of a disrupte...
Changes in the abundance and post-translational modification of proteins and accumulation of some co...
Significance: A constant accumulation of oxidized proteins takes place during aging. Oxidation of pr...
© 2020 The Authors How do cells maintain relative proportions of protein complex components? Advance...
Many Mendelian monogenic disorders are caused by loss of the function of a single protein. This can ...
Aging is a universal phenomenon that is even observed in inorganic material. In the inorganic world ...
Biological aging is often described by its phenotypic effect on individuals. Still, its causes are m...
Aging is a biological and multifactorial process characterized by a progressive and irreversible det...
Proteome and proteostasis network ( disruptions lead to proteostasis imbalances and accumulation of ...
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