Involvement of dietary saturated fats, from all sources or of dairy origin only, in insulin resistance and type 2 diabetes

Author contributions.B.M. performed the literature search, extracted and analyzed the data, wrote the man-uscript, and was the guarantor of the manuscript; A.F.contributed to the draft of the manuscript and gave final approval of the manuscript; and P.L. and J.M.L. analyzed the literature, contributed to the draft of the manuscript, and gave final approval of the manuscriptReducing the consumption of saturated fatty acids to a level as low as possible is a European public health recommendation to reduce the risk of cardiovascular disease. The association between dietary intake of saturated fatty acids and development and management of type 2 diabetes mellitus (T2DM), however, is a matter of debate. A literature search was performed to identify prospective studies and clinical trials in humans that explored the association between dietary intake of saturated fatty acids and risk of insulin resistance and T2DM. Furthermore, to assess whether specific foods, and not just the saturated fatty acid content of the food matrix, can have differential effects on human health, the relationship between consumption of full-fat dairy products, a main source of dietary saturated fatty acids, and risk of insulin resistance and T2DM was studied. There is no evidence that dietary saturated fatty acids from varied food sources affect the risk of insulin resistance or T2DM, nor is intake of full-fat dairy products associated with this risk. These findings strongly suggest that future studies on the effects of dietary saturated fatty acids should take into account the complexity of the food matrix. Furthermore, communication on saturated fats and their health effects should be prudent and well informe