International audienceThe interplay between tectonics and erosion has a predominant control on the evolution of the morphology of mountain belts. Here we investigate the modalities of deformation in Central Nepal on a c. 100 ka time scale in response to tectonic and external forcings, through the use of a finite-element thermomechanical model coupled with an integrative denudation formulation that accounts for fluvial incision and hillslope landsliding. We study the complex coupling existing between tectonics and erosion, with special emphasis on the influences of rock strength and rainfall distributions. Our results underline the key role played by lithologic variations in the elevation of both rivers and mean topography. We show that the ...