The methoxylation of N-formylpyrrolidine in a microfluidic electrolysis cell for routine synthesis
- Kuleshova, Jekaterina
- Hill-Cousins, Joseph T.
- Birkin, Peter R.
- Brown, Richard C.D.
- Pletcher, Derek
- Underwood, Toby J.
Publication date
May 2012
DOI Publisher
Elsevier BV ISSN
0013-4686 Citation count (estimate)
23Abstract
A single channel microfluidic electrolysis cell being developed for application alongside other routine microfluidic operations in the laboratory has been applied to the methoxylation of N-formylpyrrolidine. It is shown that very high conversions (?90%) in a single pass can be achieved and it is possible to obtain several grams of product per hour with a good selectivity in optimised conditions
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