As building blocks of diverse macromolecular complexes, the AAA+ ATPases Rvb1 and Rvb2 are crucial for many cellular activities including cancer-related processes. Their oligomeric structure and function remain unclear. We report the crystal structures of full-length heteromeric Rvb1·Rvb2 complexes in distinct nucleotide binding states. Chaetomium thermophilum Rvb1·Rvb2 assemble into hexameric rings of alternating molecules and into stable dodecamers. Intriguingly, the characteristic oligonucleotide-binding (OB) fold domains (DIIs) of Rvb1 and Rvb2 occupy unequal places relative to the compact AAA+ core ring. While Rvb1’s DII forms contacts between hexamers, Rvb2’s DII is rotated 100° outward, occupying lateral positions. ATP was retained b...
The ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone H2A.Z/H2B dimer for ...
The human R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1) is an HSP90 co-chaperone required for the matura...
SummaryThe ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone H2A.Z/H2B dim...
As building blocks of diverse macromolecular complexes, the AAA+ ATPases Rvb1 and Rvb2 are crucial f...
SummaryAs building blocks of diverse macromolecular complexes, the AAA+ ATPases Rvb1 and Rvb2 are cr...
SummaryThe ATPases associated with various cellular activities (AAA) protein p97 has been implicated...
SummaryThe TIP49a and TIP49b proteins belong to the family of AAA+ ATPases and play essential roles ...
Rvb1 and Rvb2 are essential proteins of the AAA+ superfamily of ATPases associated with a diversity ...
Rvb1 and Rvb2 are highly conserved and essential eukaryotic AAA+ proteins linked to a wide range of ...
International audienceRuvB-Like transcription factors function in cell cycle regulation, development...
Members of the family of ATPases associated with various cellular activities (AAA+) typically form h...
Members of the family of ATPases associated with various cellular activities (AAA+) typically form h...
ATPases of the AAA+ superfamily are large oligomeric molecular machines that remodel their substrate...
AbstractStructural maintenance of chromosome (SMC) proteins play a central role in higher-order chro...
The ubiquitous AAA-ATPase p97 segregates ubiquitylated proteins from their molecular environment. Pr...
The ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone H2A.Z/H2B dimer for ...
The human R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1) is an HSP90 co-chaperone required for the matura...
SummaryThe ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone H2A.Z/H2B dim...
As building blocks of diverse macromolecular complexes, the AAA+ ATPases Rvb1 and Rvb2 are crucial f...
SummaryAs building blocks of diverse macromolecular complexes, the AAA+ ATPases Rvb1 and Rvb2 are cr...
SummaryThe ATPases associated with various cellular activities (AAA) protein p97 has been implicated...
SummaryThe TIP49a and TIP49b proteins belong to the family of AAA+ ATPases and play essential roles ...
Rvb1 and Rvb2 are essential proteins of the AAA+ superfamily of ATPases associated with a diversity ...
Rvb1 and Rvb2 are highly conserved and essential eukaryotic AAA+ proteins linked to a wide range of ...
International audienceRuvB-Like transcription factors function in cell cycle regulation, development...
Members of the family of ATPases associated with various cellular activities (AAA+) typically form h...
Members of the family of ATPases associated with various cellular activities (AAA+) typically form h...
ATPases of the AAA+ superfamily are large oligomeric molecular machines that remodel their substrate...
AbstractStructural maintenance of chromosome (SMC) proteins play a central role in higher-order chro...
The ubiquitous AAA-ATPase p97 segregates ubiquitylated proteins from their molecular environment. Pr...
The ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone H2A.Z/H2B dimer for ...
The human R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1) is an HSP90 co-chaperone required for the matura...
SummaryThe ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone H2A.Z/H2B dim...