Safety and Efficacy of Isolated Limb Infusion Chemotherapy for Advanced Locoregional Melanoma in Elderly Patients: An Australian Multicenter Study
- Kroon, Hidde M.
- Coventry, Brendon J.
- Giles, Mitchell H.
- Henderson, Michael A.
- Speakman, David
- Wall, Mark
- Barbour, Andrew
- Serpell, Jonathan
- Paddle, Paul
- Smithers, Bernard M.
- Thompson, John F.
DOIAbstract
Background: Isolated limb infusion (ILI) offers a minimally invasive treatment option for locally advanced extremity melanoma. Objective: The aim of the current study was to evaluate the safety and efficacy of ILI in elderly patients in an Australian multicenter setting. Methods: The results of 316 first ILI procedures, performed between 1992 and 2008 in five Australian institutions, were identified and analyzed, with the main focus on elderly patients (≥75\ua0years of age). All institutions used the same protocol: melphalan was circulated in the isolated limb for 20–30\ua0min (±actinomycin D), and toxicity, responses, and survival were recorded. Results: Characteristics of patients aged ≥75\ua0years (n\ua0=\ua0148) were similar to those ag...
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