Cardiovascular effects of substance P and capsaicin microinjected into the nucleus tractus solitarii of the rat

This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration evoked changes in blood pressure and heart rate. The most sensitive sites where application of SP into the NTS evoked dose-dependent hypotension and bradycardia were at the level of the posterior tip of the area postrema (zero level) and at the level of the obex. Capsaicin evoked dose-dependent hypotension and bradycardia at the same sites. These results further support the possibility that SP may be a neurotransmitter or neuromodulator of baroreceptor afferents in the NTS