Cytokines can be used as adjuvants to enhance and direct protective immune responses induced by vaccines. IL-12, a cytokine that favors the maturation of Th1-type cells and stimulates associated cell-mediated responses was evaluated as immunologic adjuvant for a viral vaccine in a mouse challenge model. When it was administered together with inactivated pseudorabies virus, a herpes simplex virus related alpha- herpesvirus, increased production of IFN-gamma by ex vivo-stimulated splenocytes was observed as well as augmented production of antiviral serum lgG2a. This was associated with increased protection against a lethal challenge infection. Infection of IfN-gamma-neutralizing Ab reduced the increased antiviral resistance in IL-12-treated m...
To investigate whether protective immune responses can be induced in the absence of normal interleuk...
Cytokines have important regulatory functions in the interactions between effector cells and accesso...
The attenuated vaccine against Schistosoma mansoni induces Th1-mediated protective immunity and we h...
The lymphokine IFN-gamma is a pleiotropic immunomodulator and possesses intrinsic antiviral activity...
Both IL-12 and IFN-gamma have been implicated as principal inducers of type 1 immune responses requi...
Studies in IL-12-deficient mice established the necessity for IL-12 to generate a Th1 cytokine respo...
Alpha/beta interferon (IFN) and gamma IFN exert widely overlapping biological effects. Still, mice w...
Interleukin 12 (IL-12) activates natural killer (NK) and T cells with the secondary synthesis and re...
Resistance or susceptibility to most infectious diseases is strongly determined by the balance of ty...
Mice lacking the receptor for type I interferon (IFN-alpha beta, A129 mice), for type II interferon ...
An in vivo model of pulmonary granuloma formation around embolized schistosome eggs was investigated...
In mice, respiratory syncytial virus (RSV) infection during allergic provocation aggravates the alle...
To enhance the efficacy of a therapeutic immunisition strategy against human papillomavirus-induced ...
Interleukin 12 (IL-12) is an immunomodulatory cytokine with potent antitumor, antiviral and antimicr...
Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of ...
To investigate whether protective immune responses can be induced in the absence of normal interleuk...
Cytokines have important regulatory functions in the interactions between effector cells and accesso...
The attenuated vaccine against Schistosoma mansoni induces Th1-mediated protective immunity and we h...
The lymphokine IFN-gamma is a pleiotropic immunomodulator and possesses intrinsic antiviral activity...
Both IL-12 and IFN-gamma have been implicated as principal inducers of type 1 immune responses requi...
Studies in IL-12-deficient mice established the necessity for IL-12 to generate a Th1 cytokine respo...
Alpha/beta interferon (IFN) and gamma IFN exert widely overlapping biological effects. Still, mice w...
Interleukin 12 (IL-12) activates natural killer (NK) and T cells with the secondary synthesis and re...
Resistance or susceptibility to most infectious diseases is strongly determined by the balance of ty...
Mice lacking the receptor for type I interferon (IFN-alpha beta, A129 mice), for type II interferon ...
An in vivo model of pulmonary granuloma formation around embolized schistosome eggs was investigated...
In mice, respiratory syncytial virus (RSV) infection during allergic provocation aggravates the alle...
To enhance the efficacy of a therapeutic immunisition strategy against human papillomavirus-induced ...
Interleukin 12 (IL-12) is an immunomodulatory cytokine with potent antitumor, antiviral and antimicr...
Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of ...
To investigate whether protective immune responses can be induced in the absence of normal interleuk...
Cytokines have important regulatory functions in the interactions between effector cells and accesso...
The attenuated vaccine against Schistosoma mansoni induces Th1-mediated protective immunity and we h...