Myelination, the process by which oligodendrocytes form the myelin sheath around axons, is key to axonal signal transduction and related motor function in the central nervous system (CNS). Aging is characterized by degenerative changes in the myelin sheath, although the molecular underpinnings of normal and aberrant myelination remain incompletely understood. Here we report that axon myelination and related motor function are dependent on BubR1, a mitotic checkpoint protein that has been linked to progeroid phenotypes when expressed at low levels and healthy lifespan when overabundant. We found that oligodendrocyte progenitor cell proliferation and oligodendrocyte density is markedly reduced in mutant mice with low amounts of BubR1 (BubR1H/...
Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multipl...
Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multipl...
The identification of factors that regulate myelination provides important insight into the molecula...
Contains fulltext : 171765.pdf (publisher's version ) (Closed access)Myelination, ...
Contains fulltext : 174395.pdf (publisher's version ) (Open Access)Aging causes si...
Myelin is essential for efficient signal transduction in the nervous system comprising of multiple p...
Oligodendrocytes are an important cell type in the central nervous system (CNS). Their most prominen...
Although proteolipid protein (PLP) and its DM20 isoform are the major membrane proteins of CNS myeli...
The BubR1 gene encodes for a mitotic regulator that ensures accurate segregation of chromosomes thro...
175 p.Oligodendrocytes make myelin and support axons metabolically with lactate. Experience and neur...
Both the central and the peripheral nervous systems are prone to multiple age-dependent neurological...
In the central nervous system, axons are myelinated by oligodendrocytes (OLs). However, though our u...
The X-linked mutation rumpshaker (rsh), which is probably an allele of jimpy (jp), causes hypomyelin...
Efficient myelination supports nerve conduction and axonal health throughout life. In the central ne...
Myelin is indispensable for the fast and efficient transmission of electric signals along axons. Th...
Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multipl...
Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multipl...
The identification of factors that regulate myelination provides important insight into the molecula...
Contains fulltext : 171765.pdf (publisher's version ) (Closed access)Myelination, ...
Contains fulltext : 174395.pdf (publisher's version ) (Open Access)Aging causes si...
Myelin is essential for efficient signal transduction in the nervous system comprising of multiple p...
Oligodendrocytes are an important cell type in the central nervous system (CNS). Their most prominen...
Although proteolipid protein (PLP) and its DM20 isoform are the major membrane proteins of CNS myeli...
The BubR1 gene encodes for a mitotic regulator that ensures accurate segregation of chromosomes thro...
175 p.Oligodendrocytes make myelin and support axons metabolically with lactate. Experience and neur...
Both the central and the peripheral nervous systems are prone to multiple age-dependent neurological...
In the central nervous system, axons are myelinated by oligodendrocytes (OLs). However, though our u...
The X-linked mutation rumpshaker (rsh), which is probably an allele of jimpy (jp), causes hypomyelin...
Efficient myelination supports nerve conduction and axonal health throughout life. In the central ne...
Myelin is indispensable for the fast and efficient transmission of electric signals along axons. Th...
Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multipl...
Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multipl...
The identification of factors that regulate myelination provides important insight into the molecula...