CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis
- Chen, L.S.
- Hung, R.J.
- Baker, T.
- Horton, A.
- Culverhouse, R.
- Saccone, N.
- Cheng, I.
- Deng, B.
- Han, Y.
- Hansen, H.M.
- Horsman, J.
- Kim, C.
- Lutz, S.
- Rosenberger, A.
- Aben, K.K.H.
- Andrew, A.S.
- Breslau, N.
- Chang, S.C.
- Dieffenbach, A.K.
- Dienemann, H.
- Frederiksen, B.
- Han, J.
- Hatsukami, D.K.
- Johnson, E.O.
- Pande, M.
- Wrensch, M.R.
- McLaughlin, J.
- Skaug, V.
- Heijden, H.F.M. van der
- Wampfler, J.
- Wenzlaff, A.
- Woll, P.
- Zienolddiny, S.
- Bickeboller, H.
- Brenner, H.
- Duell, E.J.
- Haugen, A.
- Heinrich, J.
- Hokanson, J.E.
- Hunter, D.J.
- Kiemeney, B.
- Lazarus, P.
- Marchand, L. Le
- Liu, G.
- Mayordomo, J.
- Risch, A.
- Schwartz, A.G.
- Teare, D.
- Wu, X.
- Wiencke, J.K.
- Yang, P.
- Zhang, Z.F.
- Spitz, M.R.
- Kraft, P.
- Amos, C.I.
- Bierut, L.J.
DOIAbstract
BACKGROUND: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis. METHODS: Meta-analyses examined associations between rs16969968, age of quitting smoking, and age of lung cancer diagnosis in 24 studies of European ancestry (n = 29 072). In each dataset, we used Cox regression models to evaluate the association between rs16969968 and the two primary phenotypes (age of smoking cessation among ever smokers and age of lung cancer diagnosis among lung cancer case patients) and the secondary phenotype of smoking duration. Het...
Add to ORKG