Add to ORKGSingle enzyme molecules display inevitable, stochastic fluctuations in their catalytic activity. In metabolism, for instance, the stochastic activity of individual enzymes is averaged out due to their high copy numbers per single cell. However, many processes inside cells rely on single enzyme activity, such as transcription, replication, translation, and histone modifications. Here we introduce the main theoretical concepts of stochastic single-enzyme activity starting from the Michaelis–Menten enzyme mechanism. Next, we discuss stochasticity of multi-substrate enzymes, of enzymes and receptors with multiple conformational states and finally, how fluctuations in receptor activity arise from fluctuations in signal concentration. This paper ...
A protein undergoes conformational dynamics with multiple time scales, which results in fluctuating ...
This paper summarizes our present theoretical understanding of single-molecule kinetics associated w...
Enzymes are biological catalysts vital to life processes and have attracted century-long investigati...
AbstractSingle enzyme molecules display inevitable, stochastic fluctuations in their catalytic activ...
Single enzyme molecules display inevitable, stochastic fluctuations in their catalytic activity. In ...
Single enzyme molecules display inevitable, stochastic fluctuations in their catalytic activity. In ...
AbstractSingle enzyme molecules display inevitable, stochastic fluctuations in their catalytic activ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
The ability to dynamically probe single enzymes allows the experimental investigation of enzyme kine...
The ability to dynamically probe single enzymes allows the experimental investigation of enzyme kine...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A protein undergoes conformational dynamics with multiple time scales, which results in fluctuating ...
This paper summarizes our present theoretical understanding of single-molecule kinetics associated w...
Enzymes are biological catalysts vital to life processes and have attracted century-long investigati...
AbstractSingle enzyme molecules display inevitable, stochastic fluctuations in their catalytic activ...
Single enzyme molecules display inevitable, stochastic fluctuations in their catalytic activity. In ...
Single enzyme molecules display inevitable, stochastic fluctuations in their catalytic activity. In ...
AbstractSingle enzyme molecules display inevitable, stochastic fluctuations in their catalytic activ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
The ability to dynamically probe single enzymes allows the experimental investigation of enzyme kine...
The ability to dynamically probe single enzymes allows the experimental investigation of enzyme kine...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A growing amount of evidence over the last two decades points to the fact that many enzymes exhibit ...
A protein undergoes conformational dynamics with multiple time scales, which results in fluctuating ...
This paper summarizes our present theoretical understanding of single-molecule kinetics associated w...
Enzymes are biological catalysts vital to life processes and have attracted century-long investigati...