HIPEC treatment of peritoneal carcinomatosis in colorectal and gastric cancer

This thesis focuses on the treatment of peritoneal metastases of gastric and colorectal cancer, specifically using cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). A large part of this thesis is based on retrospective analysis of patients treated with CRS + HIPEC in the St. Antonius hospital, Nieuwegein, and Catherina Hospital, Eindhoven. By combining the patients’ databases of both hospitals, we were offered a large unique set of colorectal cancer patients treated with CRS + HIPEC. This made it possible to establish statistically significant conclusions regarding specific subgroups of patients with peritoneal carcinomatosis of colorectal cancer. Part 1 is concentrated on the early treatment of peritoneal metastases in gastric and colorectal cancer. Part 2 of this thesis explores the current borders of peritoneal carcinomatosis treatment with cytoreductive surgery and HIPEC. Part 3 is aimed at exploring the outcome of patients in whom the treatment of peritoneal carcinomatosis with CRS + HIPEC was deemed not feasible and the outcome of patients presenting with recurrent disease following a previous HIPEC procedure