textabstractViruses can exploit a variety of strategies to evade immune surveillance by cytotoxic T lymphocytes (CTL), including the acquisition of mutations in or adjacent to CTL epitopes. Recently, an amino acid substitution (R384G) in an HLA-B*2705-restricted CTL epitope in the influenza A virus nucleoprotein (nucleoprotein containing residues 383 to 391 [NP(383-391)]; SRYWAIRTR, where R is the residue that was mutated) was associated with escape from CTL-mediated immunity. The effect of this mutation on the in vitro influenza A virus-specific CTL response was studied. To this end, two influenza A viruses, one with and one without the NP(383-391) epitope, were constructed by reverse genetics and designated influenza viruses A/NL/94-384R ...
Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral protein...
Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the viru...
textabstractInfluenza A viruses accumulate amino acid substitutions in cytotoxic-T-lymphocyte (CTL) ...
Viruses can exploit a variety of strategies to evade immune surveillance by cytotoxic T lymphocytes ...
To escape immune recognition, viruses acquire amino acid substitutions in class I human leukocyte an...
Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza ...
textabstractIn the present study, we examined the effect of the loss of the human leucocyte antigen ...
Virus-specific cytotoxic T lymphocytes (CTL) contribute to the control of virus infections including...
Natural influenza A virus infections elicit both virus-specific antibody and CD4+ and CD8+ T cell re...
textabstractRecently it was shown that influenza A viruses can accumulate mutations in epitopes asso...
Current influenza virus vaccines are prepared using high-yield reassortant virus strains obtained fr...
textabstractThe repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses...
AbstractCurrent influenza virus vaccines are prepared using high-yield reassortant virus strains obt...
The repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses has been sh...
Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral protein...
Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral protein...
Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the viru...
textabstractInfluenza A viruses accumulate amino acid substitutions in cytotoxic-T-lymphocyte (CTL) ...
Viruses can exploit a variety of strategies to evade immune surveillance by cytotoxic T lymphocytes ...
To escape immune recognition, viruses acquire amino acid substitutions in class I human leukocyte an...
Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza ...
textabstractIn the present study, we examined the effect of the loss of the human leucocyte antigen ...
Virus-specific cytotoxic T lymphocytes (CTL) contribute to the control of virus infections including...
Natural influenza A virus infections elicit both virus-specific antibody and CD4+ and CD8+ T cell re...
textabstractRecently it was shown that influenza A viruses can accumulate mutations in epitopes asso...
Current influenza virus vaccines are prepared using high-yield reassortant virus strains obtained fr...
textabstractThe repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses...
AbstractCurrent influenza virus vaccines are prepared using high-yield reassortant virus strains obt...
The repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses has been sh...
Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral protein...
Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral protein...
Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the viru...
textabstractInfluenza A viruses accumulate amino acid substitutions in cytotoxic-T-lymphocyte (CTL) ...