Psychological and Neuroendocrine Determinants of Stress Regulation in Women

markdownabstractPsychosocial stress is a reaction to a real or interpreted threat to the integrity of an individual that manifests itself by biochemical, physiological, cognitive and behavioral changes. We assessed cognitive appraisal and psychophysiological responses during a standardized psychosocial stress procedure, the Trier Social Stress Task (TSST). The investigation of different factors regarding cognitive processing and psychophysiological stress response provide evidence that: - maladaptive personality traits are important factors in understanding the relationships between fundamental personality characteristics and cognitive processing during acute psychosocial stress, in both women with and without personality disorder; - the physiological response to acute psychosocial stress differs between groups with distinct personality psychopathology whereas the subjective mood disturbance response does not; - distinct hormonal contraceptive methods have contrasting effects on physiological reactivity to acute psychosocial stress in healthy women While these explorations add important clues towards a more comprehensive understanding and coherent picture of stress induced sensitivity in women, it is apparent that sex hormones play an important role, and interact with a variety of factors, including fundamental personality traits, personality pathology, genetic factors, and environmental influences, to regulate physiological reactivity and adaptation to stress, and thereby women’s individual well-being