Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
- Castaño Betancourt, Martha
- Evans, Daniel
- Ramos, Yolande
- Boer, C.G. (Cindy G.)
- Metrustry, Sarah
- Liu, Y. (Youfang)
- Hollander, Wouter
- Rooij, Jeroen
- Kraus, V.B. (Virginia B.)
- Yau, M.S. (Michelle S.)
- Mitchell, Braxton
- Muir, K. (Kenneth)
- Hofman, Albert
- Doherty, Michael
- Doherty, Sally
- Zhang, Weiya
- Kraaij, Robert
- Rivadeneira Ramirez, Fernando
- Barrett-Connor, E. (Elizabeth)
- MacIewicz, Rose
- Arden, Nigel
- Nelissen, Rob
- Kloppenburg, Margreet
- Jordan, J.M. (Joanne M.)
- Nevitt, Michael
- Slagboom, Eline
- Hart, Deborah
- Lafeber, Floris
- Styrkarsdottir, Unnur
- Zeggini, Eleftheria
- Evangelou, Evangelos
- Spector, Timothy
- Uitterlinden, André
- Lane, N.E.
- Meulenbelt, Ingrid
- Valdes, Ana Maria
- Meurs, Joyce
DOIAbstract
Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts. We identified five genome-wide significant (GWS, P≤5·0×10−8) SNPs annotated to four distinct loci. In addition, we found two additional loci that were significantly replicated, but...
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