FAM19A4 methylation analysis in self-samples compared with cervical scrapes for detecting cervical (pre)cancer in HPV-positive women
- Luttmer, Roosmarijn
- De Strooper, Lise
- Dijkstra, Maaike
- Berkhof, Johannes
- Snijders, Peter
- Steenbergen, Renske
- Kemenade, Folkert
- Rozendaal, Lawrence
- Helmerhorst, Theo
- Verheijen, René
- Harmsel, W.A.
- Baal, W.
- Graziosi, Peppino G.C.M.
- Quint, Wim
- Spruijt, Johan
- Van Dijken, D.K.E. (Dorenda K.E.)
- Heideman, Danielle
- Meijer, Chris
Publication date
August 2016
DOI Publisher
Springer Science and Business Media LLCAbstract
Background:High-risk human papillomavirus (hrHPV)-positive women require triage to identify those with cervical high-grade intraepithelial neoplasia and cancer (≥CIN3 (cervical intraepithelial neoplasia grade 3)). FAM19A4 methylation analysis, which detects advanced CIN and cancer, is applicable to different sample types. However, studies comparing the performance of FAM19A4 methylation analysis in hrHPV-positive self-samples and paired physician-taken scrapes are lacking.Methods:We compared the performance of FAM19A4 methylation analysis (and/or HPV16/18 genotyping) in self-samples and paired physician-taken scrapes for ≥CIN3 detection in hrHPV-positive women (n=450,18-66 years).Results:Overall FAM19A4 methylation levels betw
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