Dynamics of Epidermal Innervation: Role of the peptidergic and non-peptidergic nerve fibers in relation to peripheral nerve pathology

textabstractIn the present thesis the two most common peripheral nerve pathologies, peripheral nerve injury and diabetic peripheral neuropathy, were examined using preclinical animal models. Both nerve pathologies commonly lead to neuropathic pain, which is defined as pain caused by lesion or disease of the somatosensory nervous system. Manifestations of neuropathic pain features were analysed using quantitative sensory testing, electrophysiology, and skin biopsy with a focus on dynamics of epidermal innervation