Redox-Controlled Signaling in Normal Myeloid Cell Development and Leukemia

textabstractThe word hematopoiesis is derived from the greek words, haima meaning blood and poiesis meaning to make. Hematopoiesis is a tightly regulated process which ensures production of appropriate amounts of different blood cell types. All blood cell types are derived from pluripotent hematopoietic stem cells (HSCs). The HSCs are capable of self renewal. Committed myeloid progenitor cells are derived from the HSCs. Committed myeloid progenitor cells are able to proliferate and differentiate into mature blood cells like, granulocytes (neutrophils, eosinophils, basophils), lymphocytes, erythrocytes, platelets, macrophages, natural killer cells, dendritic cells and mast cells. During embryogenesis HSCs develop in the aorta-gonadmesonephros (AGM) region. HSCs migrate to the fetal liver which is the main site of hematopoiesis until birth. After birth, the bone marrow takes over as the primary site of hematopoiesis