The forkhead transcription factor FOXP1 represses human plasma cell differentiation
- Van Keimpema, Martine
- Grüneberg, Leonie J.
- Mokry, Michal
- Van Boxtel, Ruben
- Zelm, Menno
- Coffer, Paul
- Pals, S.
- Spaargaren, M.
Publication date
October 2015
DOI Publisher
American Society of HematologyAbstract
Expression of the for khead transcription factor FOXP1 is essential for early B-cell development, whereas down regulation ofFOXP1at the germinal center (GC) stage is required for GC B-cell function. Aberrantly high FOXP1 expression is frequently observed in diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma, being associated with poor prognosis. Here, by gene expression analysis upon ectopic over expression of FOXP1 in primary
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