Navigating Cells and Cytoskeletal Networks with a Novel Family of AAA-ATPases

markdownabstractThe cytoskeleton is of great importance for cell division, cell shape, cell migration and intracellular transport. This thesis describes how one of the three main cytoskeletal networks, namely the microtubule (MT) network, is regulated by MT plus-end tracking proteins (+TIPs) named “Navigators”. Furthermore, it describes the mechanisms by which two other +TIPs, named CLIP170 and EB1, associate with microtubule plus-ends