Add to ORKGtextabstractDistant regulatory sequences affect transcription through long-range chromatin interactions. Visualization of transcriptional activity of genes that compete for distant elements, using the globin locus as a model, has revealed the dynamics of chromatin interactions in vivo. Multiple genes appear to be transcribed alternately rather than at the same time to generate several messenger RNAs in one cell. The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism
International audienceRegulated gene expression, achieved through the coordinated assembly of transc...
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as...
Transcriptional control is a major mechanism for regulating gene expression. The complex machinery r...
To understand how mammalian genes are regulated from their natural chromosomal environment, we have ...
AbstractChromatin and associated regulatory proteins regulate gene expression in the natural environ...
Summary Higher-order chromosomal organization for transcription regulation is poorly understood in e...
International audienceCertain transcription factors have recently been shown to interact with DNA in...
Large-scale sequencing of the human genome has confirmed that genes are often spread over several th...
Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryote...
2 Transcription regulation is fundamental in many biological processes in all living organisms. A pa...
The mouse b-globin locus contains four genes that are expressed throughout development in the same o...
Over the last few years important new insights into the process of long-range gene regulation have b...
textabstractThe aim of this thesis was to gain a detailed understanding of transcriptional regulatio...
Chromatin interactions play important roles in transcription regulation. To better understand the un...
Administered in critical doses, drugs and chemicals can damage organs and tissues by turning numerou...
International audienceRegulated gene expression, achieved through the coordinated assembly of transc...
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as...
Transcriptional control is a major mechanism for regulating gene expression. The complex machinery r...
To understand how mammalian genes are regulated from their natural chromosomal environment, we have ...
AbstractChromatin and associated regulatory proteins regulate gene expression in the natural environ...
Summary Higher-order chromosomal organization for transcription regulation is poorly understood in e...
International audienceCertain transcription factors have recently been shown to interact with DNA in...
Large-scale sequencing of the human genome has confirmed that genes are often spread over several th...
Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryote...
2 Transcription regulation is fundamental in many biological processes in all living organisms. A pa...
The mouse b-globin locus contains four genes that are expressed throughout development in the same o...
Over the last few years important new insights into the process of long-range gene regulation have b...
textabstractThe aim of this thesis was to gain a detailed understanding of transcriptional regulatio...
Chromatin interactions play important roles in transcription regulation. To better understand the un...
Administered in critical doses, drugs and chemicals can damage organs and tissues by turning numerou...
International audienceRegulated gene expression, achieved through the coordinated assembly of transc...
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as...
Transcriptional control is a major mechanism for regulating gene expression. The complex machinery r...