Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1alpha.
- Berda-Haddad, Y.
- Robert, S.
- Salers, P.
- Zekraoui, L.
- Farnarier, C.
- Dinarello, C.A.
- Dignat-George, F.
- Kaplanski, G.
DOIAbstract
Sterile inflammation resulting from cell death is due to the release of cell contents normally inactive and sequestered within the cell; fragments of cell membranes from dying cells also contribute to sterile inflammation. Endothelial cells undergoing stress-induced apoptosis release membrane microparticles, which become vehicles for proinflammatory signals. Here, we show that stress-activated endothelial cells release two distinct populations of particles: One population consists of membrane microparticles (<1 mum, annexin V positive without DNA and no histones) and another larger (1-3 mum) apoptotic body-like particles containing nuclear fragments and histones, representing apoptotic bodies. Contrary to present concepts, endothelial micro...
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