Previous studies have demonstrated that human astrocytes express mRNA and receptor protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these receptors can influence the inflammatory and immune response and can modulate the capacity of astrocytes to produce inflammatory cytokines is still unclear. Inflammatory cytokines can be produced by activated glial cells and play a critical role in several neurological disorders. Astrocyte-enriched human cell cultures growing in a serum-free chemically defined medium were used to study the regulation of IL (interleukin)-1beta and IL-6 in response to mGluR activation. Astrocytes cultured in the absence or in the presence of epidermal growth factor (EGF), did not secrete signifi...
Recent evidence supports a role for metabotropic glutamate receptors (mGluRs) in neuroinflammatory d...
Work published over the past 10–15 years has caused the neuroscience community to engage in a proces...
AbstractWork published over the past 10–15 years has caused the neuroscience community to engage in ...
Expression of metabotropic glutamate receptor 5 (mGluR5) protein is known to be plastic and to depen...
To explore the impact of neuroinflammation on the control of glutamate transmission, we studied the ...
The chemokine RANTES is critically involved in neuroinflammation and has been implicated in the path...
<p>Treatment of astrocytes with gp120 results in the binding of gp120 by the CCR5 or CXCR4 chemokine...
While excitotoxicity and neuroinflammatory responses were clearly recognized as two essential mechan...
Interleukin-10 (IL-10) has important anti-inflammatory effects and can be protective in inflammatory...
We examined the regulation of glutamate transporter protein expression after stimulation with select...
We examined the regulation of glutamate transporter protein expression after stimulation with select...
The chemokine RANTES is critically involved in neuroinflammation and has been implicated in the path...
Microglia, the resident immune cells in the central nervous system, are implicated in the progressiv...
Although glial cells have been traditionally viewed as supportive partners of neurons, studies of th...
The group I of metabotropic glutamate (mGlu) receptor, mGlu1 and mGlu5 receptors are involved in neu...
Recent evidence supports a role for metabotropic glutamate receptors (mGluRs) in neuroinflammatory d...
Work published over the past 10–15 years has caused the neuroscience community to engage in a proces...
AbstractWork published over the past 10–15 years has caused the neuroscience community to engage in ...
Expression of metabotropic glutamate receptor 5 (mGluR5) protein is known to be plastic and to depen...
To explore the impact of neuroinflammation on the control of glutamate transmission, we studied the ...
The chemokine RANTES is critically involved in neuroinflammation and has been implicated in the path...
<p>Treatment of astrocytes with gp120 results in the binding of gp120 by the CCR5 or CXCR4 chemokine...
While excitotoxicity and neuroinflammatory responses were clearly recognized as two essential mechan...
Interleukin-10 (IL-10) has important anti-inflammatory effects and can be protective in inflammatory...
We examined the regulation of glutamate transporter protein expression after stimulation with select...
We examined the regulation of glutamate transporter protein expression after stimulation with select...
The chemokine RANTES is critically involved in neuroinflammation and has been implicated in the path...
Microglia, the resident immune cells in the central nervous system, are implicated in the progressiv...
Although glial cells have been traditionally viewed as supportive partners of neurons, studies of th...
The group I of metabotropic glutamate (mGlu) receptor, mGlu1 and mGlu5 receptors are involved in neu...
Recent evidence supports a role for metabotropic glutamate receptors (mGluRs) in neuroinflammatory d...
Work published over the past 10–15 years has caused the neuroscience community to engage in a proces...
AbstractWork published over the past 10–15 years has caused the neuroscience community to engage in ...