Extensive exploration of simulation models comes at a high computational cost, all the more when the model involves a lot of parameters. Economists usually rely on random explorations, such as Monte Carlo simulations, and basic econometric modeling to approximate the properties of computational models. This paper aims to provide guidelines for the use of a much more efficient method that combines a parsimonious sampling of the parameter space using a specific design of experiments (DoE), with a well-suited metamodeling method first developed in geostatistics: kriging. We illustrate these guidelines by following them in the analysis of two simple and well known economic models: Nelson and Winter’s industrial dynamics model, and Cournot oligo...