Follow-Up of Patients with Multidrug Resistant Tuberculosis Four Years after Standardized First-Line Drug Treatment

He, G.X.
Xie, Y.G.
Wang, L.X.
Borgdorff, M.W.
van der Werf, M.J.
Fan, J.H.
Yan, X.L.
Li, F.B.
Zhang, X.Z.
Zhao, Y.L.
van den Hof, S.

Open link

Publication date

January 2010

DOI

10.1371/journal.pone.0010799

Publisher

Public Library of Science (PLoS)

Abstract

Background: In 2004, an anti-tuberculosis (TB) drug resistance survey in Heilongjiang province, China, enrolled 1574 (79%) new and 421 (21%) retreatment patients. Multi-drug resistant (MDR) TB was detected in 7.2% of new and 30.4% of retreatment patients. All received treatment with standardized first-line drug (FLD) regimens. Methodology/Principal Findings: We report treatment outcomes of the 2004 cohort, and long-term outcomes as assessed in the second half of 2008. The reported cure rate for MDR-TB patients was 83% (94/113) among new and 66% (85/128) among retreatment patients (P<0.001). Ten of the 241 MDR-TB patients died during treatment. Of the remaining 231, 129 (56%) could be traced in 2008. The overall recurrence rates among new an...