In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment of a stent, is a multiscale system involving a large number of biological and physical processes. We describe a Complex Automata model for in-stent restenosis, coupling bulk flow, drug diffusion, and smooth muscle cell models, all operating on different time scales. Details of the single scale models and of the coupling interfaces are described, together with first simulation results, obtained with a dedicated software environment for Complex Automata simulations. Preliminary results show that the model can reproduce growth trends observed in experimental studies and facilitate testing of hypotheses concerning the interaction of key factors
While animal models are widely used to investigate the development of restenosis in blood vessels fo...
Since their first introduction, stents have revolutionised the treatment of atherosclerosis, however...
Neointimal hyperplasia, a process of smooth muscle cell re-growth, is the result of a natural wound ...
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment o...
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment o...
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment o...
COAST (Complex Automata Simulation Technique) is a European Union FP6 funded project which has devel...
www.complex-automata.org A simplified description of the system in terms of relevant scales is drawn...
We describe our fully-coupled 3D multiscale model of in-stent restenosis, with blood flow simulation...
In this thesis a fully-coupled 3D multiscale computational model of in-stent restenosis is developed...
The process can be categorized in various stages:- initial injury;- an inflammatory stage;- granulat...
The inherent complexity of biomedical systems is well recognized; they are multiscale, multiscience ...
: In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries to per...
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries to percu...
The stenting procedure has evolved to become a highly successful technique for the clinical treatmen...
While animal models are widely used to investigate the development of restenosis in blood vessels fo...
Since their first introduction, stents have revolutionised the treatment of atherosclerosis, however...
Neointimal hyperplasia, a process of smooth muscle cell re-growth, is the result of a natural wound ...
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment o...
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment o...
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment o...
COAST (Complex Automata Simulation Technique) is a European Union FP6 funded project which has devel...
www.complex-automata.org A simplified description of the system in terms of relevant scales is drawn...
We describe our fully-coupled 3D multiscale model of in-stent restenosis, with blood flow simulation...
In this thesis a fully-coupled 3D multiscale computational model of in-stent restenosis is developed...
The process can be categorized in various stages:- initial injury;- an inflammatory stage;- granulat...
The inherent complexity of biomedical systems is well recognized; they are multiscale, multiscience ...
: In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries to per...
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries to percu...
The stenting procedure has evolved to become a highly successful technique for the clinical treatmen...
While animal models are widely used to investigate the development of restenosis in blood vessels fo...
Since their first introduction, stents have revolutionised the treatment of atherosclerosis, however...
Neointimal hyperplasia, a process of smooth muscle cell re-growth, is the result of a natural wound ...