Add to ORKGBACKGROUND & AIMS: In colorectal cancer, activating mutations in the Wnt pathway transform epithelial cells through the inappropriate expression of a TCF4 target gene program, which is physiologically expressed in intestinal crypts. METHODS: We have now performed an exhaustive array-based analysis of this target gene program in colorectal cancer cell lines carrying an inducible block of the Wnt cascade. Independently, differential gene-expression profiles of human adenomas and adenocarcinomas vs normal colonic epithelium were obtained. RESULTS: Expression analyses of approximately 80 genes common between these data sets were performed in a murine adenoma model. The combined data sets describe a core target gene program, the intestinal Wnt/T...
Background: Deregulation of canonical Wnt/CTNNB1 (beta-catenin) pathway is one of the earliest event...
Surprisingly few pathways signal between cells, raising questions about mechanisms for tissue-specif...
Expression profiling is a well established tool for the genome-wide analysis of human cancers. Howev...
BACKGROUND & AIMS: In colorectal cancer, activating mutations in the Wnt pathway transform epithelia...
The intestinal epithelium is a specialized simple epithelium that lines the gut and performs primary...
BACKGROUND: Cancer results from the accumulation of mutations leading to the acquisition of cancer p...
In order to identify new genes with differential expression in early intestinal tumours, we performe...
In order to identify new genes with differential expression in early intestinal tumours, we performe...
Abstract: Background: Cancer results from the accumulation of mutations leading to the acquisition o...
The transition of an intestinal epithelial cell into a fully transformed, metastatic cancer cell req...
Canonical wnt signaling is important in embryonic development and tumorigenesis of various tissues i...
For more than 20 years, T-cell specific factor 4 (Tcf4) is the most intensively studied member of th...
Wnt signalling, which is transduced through beta-catenin/TCF4, maintains the undifferentiated state ...
T-cell factor 4 (TCF4), together with β-catenin coactivator, functions as the major transcripti...
The intestinal epithelium is a self-renewing tissue that represents a unique model for studying inte...
Background: Deregulation of canonical Wnt/CTNNB1 (beta-catenin) pathway is one of the earliest event...
Surprisingly few pathways signal between cells, raising questions about mechanisms for tissue-specif...
Expression profiling is a well established tool for the genome-wide analysis of human cancers. Howev...
BACKGROUND & AIMS: In colorectal cancer, activating mutations in the Wnt pathway transform epithelia...
The intestinal epithelium is a specialized simple epithelium that lines the gut and performs primary...
BACKGROUND: Cancer results from the accumulation of mutations leading to the acquisition of cancer p...
In order to identify new genes with differential expression in early intestinal tumours, we performe...
In order to identify new genes with differential expression in early intestinal tumours, we performe...
Abstract: Background: Cancer results from the accumulation of mutations leading to the acquisition o...
The transition of an intestinal epithelial cell into a fully transformed, metastatic cancer cell req...
Canonical wnt signaling is important in embryonic development and tumorigenesis of various tissues i...
For more than 20 years, T-cell specific factor 4 (Tcf4) is the most intensively studied member of th...
Wnt signalling, which is transduced through beta-catenin/TCF4, maintains the undifferentiated state ...
T-cell factor 4 (TCF4), together with β-catenin coactivator, functions as the major transcripti...
The intestinal epithelium is a self-renewing tissue that represents a unique model for studying inte...
Background: Deregulation of canonical Wnt/CTNNB1 (beta-catenin) pathway is one of the earliest event...
Surprisingly few pathways signal between cells, raising questions about mechanisms for tissue-specif...
Expression profiling is a well established tool for the genome-wide analysis of human cancers. Howev...