In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentration-dependent induction of six different cell populations mediated through Gli transcriptional regulators. Elsewhere in the embryo, Shh/Gli responses invoke different tissue-appropriate regulatory programs. A genome-scale analysis of DNA binding by Gli1 and Sox2, a pan-neural determinant, identified a set of shared regulatory regions associated with key factors central to cell fate determination and neural tube patterning. Functional analysis in transgenic mice validates core enhancers for each of these factors and demonstrates the dual requirement for Gli1 and Sox2 inputs for neural enhancer activity. Furthermore, through an unbiased determ...
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vi...
AbstractGLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissu...
AbstractGLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissu...
In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentra...
In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentra...
In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic patte...
Sonic hedgehog (Shh) signaling patterns the vertebrate spinal cord by activating a group of transcri...
AbstractSonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, whic...
SummaryMorphogens orchestrate tissue patterning in a concentration-dependent fashion during vertebra...
The Sonic hedgehog (Shh) pathway plays an important role in the development of many tissues and orga...
AbstractSonic hedgehog (Shh) directs the development of ventral cell fates, including floor plate an...
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vi...
Secreted signals, known as morphogens, provide the positional information that organizes gene expres...
SummarySecreted signals, known as morphogens, provide the positional information that organizes gene...
AbstractThe partitioning of the ventral neural tube into five distinct neuronal progenitor domains i...
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vi...
AbstractGLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissu...
AbstractGLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissu...
In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentra...
In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentra...
In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic patte...
Sonic hedgehog (Shh) signaling patterns the vertebrate spinal cord by activating a group of transcri...
AbstractSonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, whic...
SummaryMorphogens orchestrate tissue patterning in a concentration-dependent fashion during vertebra...
The Sonic hedgehog (Shh) pathway plays an important role in the development of many tissues and orga...
AbstractSonic hedgehog (Shh) directs the development of ventral cell fates, including floor plate an...
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vi...
Secreted signals, known as morphogens, provide the positional information that organizes gene expres...
SummarySecreted signals, known as morphogens, provide the positional information that organizes gene...
AbstractThe partitioning of the ventral neural tube into five distinct neuronal progenitor domains i...
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vi...
AbstractGLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissu...
AbstractGLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissu...