The effect of purifed human activated protein C (APC) on fibrinolysis was studied by using in vitro clot lysis techniques. Clots were formed from citrated blood or plasma (supplemented with 125I-labeled fibrinogen) by adding thrombin and Ca2+-ions; lysis of the clots was achieved by the addition of tissue-type plasminogen activator before clot formation. The gradual release of labeled fibrin degradation products from the clot into the supernatant was taken as a measure for the lysis rate. It was demonstrated that the acceleration of clot lysis by APC added before clot formation depends on the presence of Protein S, Ca2+-ions and phospholipids. These observations suggest a role of APC as anticoagulant in clot lysis, since the cofactors for t...
Thrombin-activatable fibrinolysis inhibitor (TAFI) is the pre-cursor of an exopeptidase that is iden...
Factor Va is the essential cofactor in prothrombinase-dependent activation of prothrombin. Resistanc...
Thrombin cleaves single-chain urokinase-type plasminogen activator (scu- PA) into a virtually inacti...
The effect of purified human activated protein C (APC) and protein S on fibrinolysis was studied by ...
Confluent cultures of endothelial cells from human umbilical cord were used to study the effect of a...
A natural anticoagulant pathway denoted the protein C system provides specific and efficient control...
tered intravenously to dogs, increases the rate oflysis of whole blood clots. Protein C, bovine prot...
Thrombosis is the leading cause of death and disability. Clots (i.e. thrombi) that obstruct blood fl...
Human protein C was purified. and the mechanism of action of activated protein C as an anticoagulant...
BACKGROUND: Low levels of activated protein C (APC) are a risk factor for venous thrombosis. The mec...
Activated protein C (APC) is a potent physiologic anticoag-ulant with profibrinolytic properties, an...
The protein C system provides important control of blood coagulation by regulating the activities of...
IntroductionAcute traumatic coagulopathy has been associated with shock and tissue injury, and may b...
Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a seri...
The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhi...
Thrombin-activatable fibrinolysis inhibitor (TAFI) is the pre-cursor of an exopeptidase that is iden...
Factor Va is the essential cofactor in prothrombinase-dependent activation of prothrombin. Resistanc...
Thrombin cleaves single-chain urokinase-type plasminogen activator (scu- PA) into a virtually inacti...
The effect of purified human activated protein C (APC) and protein S on fibrinolysis was studied by ...
Confluent cultures of endothelial cells from human umbilical cord were used to study the effect of a...
A natural anticoagulant pathway denoted the protein C system provides specific and efficient control...
tered intravenously to dogs, increases the rate oflysis of whole blood clots. Protein C, bovine prot...
Thrombosis is the leading cause of death and disability. Clots (i.e. thrombi) that obstruct blood fl...
Human protein C was purified. and the mechanism of action of activated protein C as an anticoagulant...
BACKGROUND: Low levels of activated protein C (APC) are a risk factor for venous thrombosis. The mec...
Activated protein C (APC) is a potent physiologic anticoag-ulant with profibrinolytic properties, an...
The protein C system provides important control of blood coagulation by regulating the activities of...
IntroductionAcute traumatic coagulopathy has been associated with shock and tissue injury, and may b...
Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a seri...
The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhi...
Thrombin-activatable fibrinolysis inhibitor (TAFI) is the pre-cursor of an exopeptidase that is iden...
Factor Va is the essential cofactor in prothrombinase-dependent activation of prothrombin. Resistanc...
Thrombin cleaves single-chain urokinase-type plasminogen activator (scu- PA) into a virtually inacti...