In passenger transport, hub-and-spoke networks allow the transportation of small passenger flows with competitive frequencies, in a way that direct line networks cannot. Equivalently, in freight transport, it can be expected that small shipper-receiver flows of high added value commodities transit through hub and spoke networks, while larger shipper-receiver flows of less expensive commodities are transported directly, without transhipment. The objective of this paper is first to present an analytical model, based on inventory theory, explaining how for a given commodity flow, the organisation of freight transport operations is closely related to the characteristics of the shipper-receiver relationship; second to assess empirically this mod...