We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological diseases. CD40L-positive cells were co-localized with CD40-bearing cells in active lesions (perivascular infiltrates). Most of these CD40 bearing cells proved to be of the monocytic lineage (macrophages or microglial cells), and relatively few were B cells. To functionally evaluate CD40-CD40L interactions, EAE was elicited in mice by means of proteolipid-peptide immunization. Treatment with anti-CD40L monoclo...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
The CD40-CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune ...
The CD40-CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune ...
We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and exp...
The interactions of CD40 and CD40L have been known for some time to critically regulate B-cell respo...
The costimulatory CD40L–CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly expr...
The co-stimulatory CD40L-CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly exp...
CD40 ligand-CD40 interactions are important in the development of experimental autoimmune encephalom...
Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L), expresse...
<div><p>CD40-CD154 interaction is critically involved in autoimmune diseases, and CD4 T cells play a...
Immune-inflammatory conditions in the central nervous system (CNS) rely on molecular and cellular in...
Relapsing experimental autoimmune encephalomyelitis (R-EAE) in the SJL mouse is a Th1-mediated autoi...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
The CD40-CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune ...
The CD40-CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune ...
We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and exp...
The interactions of CD40 and CD40L have been known for some time to critically regulate B-cell respo...
The costimulatory CD40L–CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly expr...
The co-stimulatory CD40L-CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly exp...
CD40 ligand-CD40 interactions are important in the development of experimental autoimmune encephalom...
Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L), expresse...
<div><p>CD40-CD154 interaction is critically involved in autoimmune diseases, and CD4 T cells play a...
Immune-inflammatory conditions in the central nervous system (CNS) rely on molecular and cellular in...
Relapsing experimental autoimmune encephalomyelitis (R-EAE) in the SJL mouse is a Th1-mediated autoi...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...
Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development ...