Retinoid (vitamin A) metabolism : a review

Objective and conclusion: An overview is given of our understanding of the uptake and metabolism of retinoids. The mechanisms underlying retinol uptake by organs and tissues are still unsettled. The retinol-binding proteins CRBP I and CRBP II appear to play an essential role in retinyl ester hydrolysis and formation and in retinoic acid formation. Chemicals/CAS: Carboxylic Ester Hydrolases, EC 3.1.1.-; Receptors, Cell Surface; Receptors, Retinoic Acid; Retinoids; retinol binding protein receptor; retinyl esterase, EC 3.1.1.-; Tretinoin, 302-79-4; Vitamin A, 11103-57-