Add to ORKGThe effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001<P<0.05). During differentiation Caco-2 cells formed 5 phase II metabolites, of which the amount of 4′-O-methyl-quercetin-3′-O-glucuronide correlated with the differentiation grade (r=0.99, P<0.003). The increment of cell proliferation at low quercetin concentrations and the decrease in cell differentiation are effects opposite to what would be expected for a functional food ingredient with anti-carcinogenic potential. © 2005 Elsevier Ireland Ltd. All rights re...
Therapy with 5-fluorouracil (5-FU) as a single agent has only limited success in palliative treatmen...
Resistance to chemotherapeutic drugs is a major problem in cancer treatment. The search for new inte...
Pancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing w...
The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation ...
Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these c...
The aim was to investigate mechanisms contributing to quercetin's previously described effects on ce...
Background Many different mechanisms are involved in nutrient¿related prevention of colon cancer. In...
The consumption of vegetables containing the flavonols quercetin and kaempferol reduces the risk of ...
Quercetin, a natural polyphenolic flavonoid compound, can inhibit the growth of several malignant ca...
Abstract The development of the resistance to antineoplastic drugs is a major issue in the cancer t...
Colorectal cancer (CRC) is the third most common type of cancer and the fourth most common cause of ...
Abstract Background High fruit and vegetable intake is known to reduce the risk of colon cancer. To ...
AbstractQuercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We ...
Colorectal cancer (CRC) is hypothesized to be prevented by intake of fruits and vegetables that cont...
ABSTRACTQuercetin, a flavonoid, is a dietary component that has attracted the attention of dietitian...
Therapy with 5-fluorouracil (5-FU) as a single agent has only limited success in palliative treatmen...
Resistance to chemotherapeutic drugs is a major problem in cancer treatment. The search for new inte...
Pancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing w...
The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation ...
Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these c...
The aim was to investigate mechanisms contributing to quercetin's previously described effects on ce...
Background Many different mechanisms are involved in nutrient¿related prevention of colon cancer. In...
The consumption of vegetables containing the flavonols quercetin and kaempferol reduces the risk of ...
Quercetin, a natural polyphenolic flavonoid compound, can inhibit the growth of several malignant ca...
Abstract The development of the resistance to antineoplastic drugs is a major issue in the cancer t...
Colorectal cancer (CRC) is the third most common type of cancer and the fourth most common cause of ...
Abstract Background High fruit and vegetable intake is known to reduce the risk of colon cancer. To ...
AbstractQuercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We ...
Colorectal cancer (CRC) is hypothesized to be prevented by intake of fruits and vegetables that cont...
ABSTRACTQuercetin, a flavonoid, is a dietary component that has attracted the attention of dietitian...
Therapy with 5-fluorouracil (5-FU) as a single agent has only limited success in palliative treatmen...
Resistance to chemotherapeutic drugs is a major problem in cancer treatment. The search for new inte...
Pancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing w...