In lung fibrosis tissue architecture and function is severely hampered by myofibroblasts due to excessive deposition of extracellular matrix and tissue contraction. Myofibroblasts differentiate from fibroblasts under the influence of transforming growth factor (TGF) β<sub>1</sub> but this process is also controlled mechanically by cytoskeletal tension. In healthy lungs, the cytoskeleton of fibroblasts is mechanically strained during breathing. In stiffer fibrotic lung tissue, this mechanical stimulus is reduced, which may influence fibroblast-to-myofibroblast differentiation. Therefore, we investigated the effect of cyclic mechanical stretch on fibroblast-to-myofibroblast differentiation.Primary normal human lung fibroblasts were grown on B...
Pulmonary fibrosis (PF) is a progressive disease that disrupts the mechanical homeostasis of the lun...
<p>A) Immunohistochemical staining for α-smooth muscle actin (α-SMA), the contractile element in myo...
© 2019 Dr. Asres Berhan MitkeFibrosis is one of the leading causes of death that may affect all orga...
In lung fibrosis tissue architecture and function is severely hampered by myofibroblasts due to exce...
AbstractIn lung fibrosis tissue architecture and function is severely hampered by myofibroblasts due...
Although dermal fibroblasts receive stretch and relaxation exerted by muscle movement, biological ef...
Cardiac fibrosis is the excessive accumulation of extra-cellular matrix that is mainly regulated by ...
The extracellular matrix (ECM) supports lung tissue architecture and physiology by providing mechani...
Reprinted with permission of the American Thoracic Society. Copyright © 2015 American Thoracic Socie...
The mechanical properties of the extracellular matrix have recently been shown to promote myofibrobl...
Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affect...
Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affect...
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a resul...
The contribution of epithelial-to-mesenchymal transition (EMT) to the profibrotic stiff microenviron...
© 2018 the American Physiological Society and American Physiological Society. All rights reserved. I...
Pulmonary fibrosis (PF) is a progressive disease that disrupts the mechanical homeostasis of the lun...
<p>A) Immunohistochemical staining for α-smooth muscle actin (α-SMA), the contractile element in myo...
© 2019 Dr. Asres Berhan MitkeFibrosis is one of the leading causes of death that may affect all orga...
In lung fibrosis tissue architecture and function is severely hampered by myofibroblasts due to exce...
AbstractIn lung fibrosis tissue architecture and function is severely hampered by myofibroblasts due...
Although dermal fibroblasts receive stretch and relaxation exerted by muscle movement, biological ef...
Cardiac fibrosis is the excessive accumulation of extra-cellular matrix that is mainly regulated by ...
The extracellular matrix (ECM) supports lung tissue architecture and physiology by providing mechani...
Reprinted with permission of the American Thoracic Society. Copyright © 2015 American Thoracic Socie...
The mechanical properties of the extracellular matrix have recently been shown to promote myofibrobl...
Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affect...
Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affect...
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a resul...
The contribution of epithelial-to-mesenchymal transition (EMT) to the profibrotic stiff microenviron...
© 2018 the American Physiological Society and American Physiological Society. All rights reserved. I...
Pulmonary fibrosis (PF) is a progressive disease that disrupts the mechanical homeostasis of the lun...
<p>A) Immunohistochemical staining for α-smooth muscle actin (α-SMA), the contractile element in myo...
© 2019 Dr. Asres Berhan MitkeFibrosis is one of the leading causes of death that may affect all orga...