Background-Nebivolol is a beta-selective adrenergic receptor antagonist with proposed nitric oxide (NO)-mediated vasodilating properties in humans. In this study, we explored whether nebivolol indeed induces NO production and, if so, by what mechanism. We hypothesized that not nebivolol itself but rather its metabolites augment NO production. Methods and Results-Mouse thoracic aorta segments were bathed in an organ chamber. Administration of nebivolol did not affect NO production. When nebivolol was allowed to metabolize in vivo in mice, addition of plasma of these mice caused a sustained 2-fold increase in NO release. Interestingly, coadministration of a selective beta(2)-adrenergic receptor antagonist (butoxamine) prevented the response. ...
Nebivolol is a highly selective beta(1)-adrenoceptor blocker, which also stimulates endothelial nitr...
Nebivolol is a newer beta(1)-selective adrenergic receptor antagonist, which unlike classic beta-blo...
Nebivolol is a recently developed b-blocker provided with vaso-dilator properties. Because the mecha...
Background-Nebivolol is a beta-selective adrenergic receptor antagonist with proposed nitric oxide (...
BACKGROUND: Nebivolol is a selective beta(1)-adrenergic receptor antagonist that causes a direct vas...
Background: Nebivolol is a selective β1-adrenergic receptor antagonist that causes a direct vasodila...
Background: Nebivolol is a selective β1-adrenergic receptor antagonist that causes a direct vasodila...
BACKGROUND: The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, th...
Nebivolol is a beta1-adrenergic receptor antagonist that also reduces blood pressure by evoking endo...
Nebivolol is a beta 1-adrenergic receptor antagonist that also reduces blood pressure by evoking end...
Background—The therapeutic effects of nonspecific -blockers are limited by vasoconstriction, thus ju...
The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, thus justifyin...
β-blockers are among the most widely used drugs in the prevention and treatment of cardiovascular di...
Nebivolol, a third generation selective beta(1)-adrenoceptor (beta(1)-AR) antagonist, has been repor...
Nebivolol is a highly selective β 1-adrenoceptor blocker, which also stimulates endothelial nitric o...
Nebivolol is a highly selective beta(1)-adrenoceptor blocker, which also stimulates endothelial nitr...
Nebivolol is a newer beta(1)-selective adrenergic receptor antagonist, which unlike classic beta-blo...
Nebivolol is a recently developed b-blocker provided with vaso-dilator properties. Because the mecha...
Background-Nebivolol is a beta-selective adrenergic receptor antagonist with proposed nitric oxide (...
BACKGROUND: Nebivolol is a selective beta(1)-adrenergic receptor antagonist that causes a direct vas...
Background: Nebivolol is a selective β1-adrenergic receptor antagonist that causes a direct vasodila...
Background: Nebivolol is a selective β1-adrenergic receptor antagonist that causes a direct vasodila...
BACKGROUND: The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, th...
Nebivolol is a beta1-adrenergic receptor antagonist that also reduces blood pressure by evoking endo...
Nebivolol is a beta 1-adrenergic receptor antagonist that also reduces blood pressure by evoking end...
Background—The therapeutic effects of nonspecific -blockers are limited by vasoconstriction, thus ju...
The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, thus justifyin...
β-blockers are among the most widely used drugs in the prevention and treatment of cardiovascular di...
Nebivolol, a third generation selective beta(1)-adrenoceptor (beta(1)-AR) antagonist, has been repor...
Nebivolol is a highly selective β 1-adrenoceptor blocker, which also stimulates endothelial nitric o...
Nebivolol is a highly selective beta(1)-adrenoceptor blocker, which also stimulates endothelial nitr...
Nebivolol is a newer beta(1)-selective adrenergic receptor antagonist, which unlike classic beta-blo...
Nebivolol is a recently developed b-blocker provided with vaso-dilator properties. Because the mecha...