Lymph node retrieval during esophagectomy with and without neoadjuvant chemoradiotherapy: prognostic and therapeutic impact on survival.
- Koen Talsma, A.
- Shapiro, J.
- Looman, C.W.
- Hagen, P. van
- Steyerberg, E.W.
- Gaast, A. van der
- Berge Henegouwen, M.I. van
- Wijnhoven, B.P.
- Lanschot, J.J. van
- Hulshof, M.C.C.
- Laarhoven, H.W.M. van
- Nieuwenhuijzen, G.A.
- Hospers, G.A.
- Bonenkamp, J.J.
- Cuesta, M.A.
- Blaisse, R.J.
- Busch, O.R.
- Kate, F.J. ten
- Creemers, G.J.
- Punt, C.J.A.
- Plukker, J.T.
- Verheul, H.M.
- Dekken, H. van
- Sangen, M.J. van der
- Rozema, T.
- Biermann, K.
- Beukema, J.C.
- Piet, A.H.
- Rij, C.M van
- Reinders, J.G.
- Tilanus, H.W.
DOIAbstract
OBJECTIVES: We aimed to examine the association between total number of resected nodes and survival in patients after esophagectomy with and without nCRT. BACKGROUND: Most studies concerning the potentially positive effect of extended lymphadenectomy on survival have been performed in patients who underwent surgery alone. As nCRT is known to frequently "sterilize" regional nodes, it is unclear whether extended lymphadenectomy after nCRT is still useful. METHODS: Patients from the randomized CROSS-trial who completed the entire protocol (ie, surgery alone or chemoradiotherapy + surgery) were included. With Cox regression models, we compared the impact of number of resected nodes as well as resected positive nodes on survival in both groups. ...
Add to ORKG