The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial
- Eijk, L.T.G.J. van
- Heemskerk, S.
- Pluijm, R.W. van der
- Wijk, S.M. van
- Peters, W.H.M.
- Hoeven, J.G. van der
- Kox, M.
- Swinkels, D.W.
- Pickkers, P.
DOIAbstract
In this double-blind randomized placebo-controlled trial involving 30 healthy male volunteers we investigated the acute effects of iron loading (single dose of 1.25 mg/kg iron sucrose) and iron chelation therapy (single dose of 30 mg/kg deferasirox) on iron parameters, oxidative stress, the innate immune response, and subclinical organ injury during experimental human endotoxemia. The administration of iron sucrose induced a profound increase in plasma malondialdehyde 1 h after administration (433+/-37% of baseline; P<0.0001), but did not potentiate the endotoxemia-induced increase in malondialdehyde, as was seen 3 h after endotoxin administration in the placebo group (P=0.34) and the iron chelation group (P=0.008). Endotoxemia resulted in ...
_complex.png%3Fwidth%3D300&w=3840&q=75)
Add to ORKG