BACKGROUND: Genome-wide association studies have convincingly shown that single nucleotide polymorphisms (SNPs) in HFE and TMPRSS6 are associated with iron parameters. It was commonly thought that these associations could be explained by the intermediate effect on hepcidin concentration. A recent study in an isolated Italian population, however, concluded that these associations were not exclusively dependent on hepcidin values. We report here the second study to investigate the role of hepcidin in the associations between common variants in HFE and TMPRSS6 with iron parameters. METHODS: We extracted 101 SNPs in HFE and TMPRSS6 from genome-wide imputed SNP data of 1832 individuals from the general population (Nijmegen Biomedical Study). Sin...
TMPRSS6 gene mutations can result in iron deficiency anemia (IDA) and cause an increased iron-regula...
The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to i...
BACKGROUND: Iron is integral to many physiological processes, and variations in its levels, even wit...
Background Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin ...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
Background: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major geneti...
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMR...
Background: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major geneti...
Genome-wide association studies in Europeans and Asians have identified numerous variants in the tra...
<div><p>The existence of multiple inherited disorders of iron metabolism suggests genetic contributi...
The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to i...
TMPRSS6 gene mutations can result in iron deficiency anemia (IDA) and cause an increased iron-regula...
The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to i...
BACKGROUND: Iron is integral to many physiological processes, and variations in its levels, even wit...
Background Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin ...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
The genetic determinants of variation in iron status are actively sought, but remain incompletely un...
Background: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major geneti...
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMR...
Background: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major geneti...
Genome-wide association studies in Europeans and Asians have identified numerous variants in the tra...
<div><p>The existence of multiple inherited disorders of iron metabolism suggests genetic contributi...
The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to i...
TMPRSS6 gene mutations can result in iron deficiency anemia (IDA) and cause an increased iron-regula...
The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to i...
BACKGROUND: Iron is integral to many physiological processes, and variations in its levels, even wit...