Adaptive decision-making involves interaction between systems regulating Pavlovian and instrumental control of behavior. Here we investigate in humans the role of serotonin in such Pavlovian-instrumental transfer in both the aversive and the appetitive domain using acute tryptophan depletion, known to lower central serotonin levels. Acute tryptophan depletion attenuated the inhibiting effect of aversive Pavlovian cues on instrumental behavior, while leaving unaltered the activating effect of appetitive Pavlovian cues. These data suggest that serotonin is selectively involved in Pavlovian inhibition due to aversive expectations and have implications for our understanding of the mechanisms underlying a range of affective, impulsive, and aggre...
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarka...
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarka...
The neurotransmitter serotonin has long been implicated in the motivational control of behaviour. Re...
Rationale Human motivation and decision-making is influenced by the interaction of Pavlovian and ins...
Updated theoretical accounts of the role of serotonin (5-HT) in motivation propose that 5-HT operate...
The neuromodulator serotonin has been implicated in a large number of affective and executive functi...
Updated theoretical accounts of the role of serotonin (5-HT) in motivation propose that 5-HT operate...
Serotonin is involved in updating responses to changing environmental circumstances. Optimising beha...
BACKGROUND: Optimal behavioral performance results from a balance between goal-directed and habitual...
Human decision-making arises from both reflective and reflexive mechanisms, which underpin goal-dire...
Learning of associations between aversive stimuli and predictive cues is the basis of Pavlovian fear...
Learning of associations between aversive stimuli and predictive cues is the basis of Pavlovian fear...
Impairments in emotional reactivity and behavioural flexibility are pervasive across disparate psych...
While accumulating evidence suggests that effective real-life decision-making depends upon the funct...
RATIONALE: We have previously shown that tryptophan depletion enhances punishment but not reward pre...
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarka...
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarka...
The neurotransmitter serotonin has long been implicated in the motivational control of behaviour. Re...
Rationale Human motivation and decision-making is influenced by the interaction of Pavlovian and ins...
Updated theoretical accounts of the role of serotonin (5-HT) in motivation propose that 5-HT operate...
The neuromodulator serotonin has been implicated in a large number of affective and executive functi...
Updated theoretical accounts of the role of serotonin (5-HT) in motivation propose that 5-HT operate...
Serotonin is involved in updating responses to changing environmental circumstances. Optimising beha...
BACKGROUND: Optimal behavioral performance results from a balance between goal-directed and habitual...
Human decision-making arises from both reflective and reflexive mechanisms, which underpin goal-dire...
Learning of associations between aversive stimuli and predictive cues is the basis of Pavlovian fear...
Learning of associations between aversive stimuli and predictive cues is the basis of Pavlovian fear...
Impairments in emotional reactivity and behavioural flexibility are pervasive across disparate psych...
While accumulating evidence suggests that effective real-life decision-making depends upon the funct...
RATIONALE: We have previously shown that tryptophan depletion enhances punishment but not reward pre...
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarka...
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarka...
The neurotransmitter serotonin has long been implicated in the motivational control of behaviour. Re...