ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
- Faraco, J.
- Lin, L.
- Kornum, B.R.
- Kenny, E.E.
- Trynka, G.
- Einen, M.
- Rico, T.J.
- Lichtner, P.
- Dauvilliers, Y.
- Arnulf, I.
- Lecendreux, M.
- Javidi, S.
- Geisler, P.
- Mayer, G.
- Pizza, F.
- Poli, F.
- Plazzi, G.
- Overeem, S.
- Lammers, G.J.
- Kemlink, D.
- Sonka, K.
- Nevsimalova, S.
- Rouleau, G.
- Desautels, A.
- Montplaisir, J.
- Frauscher, B.
- Ehrmann, L.
- Hogl, B.
- Jennum, P.
- Bourgin, P.
- Peraita-Adrados, R.
- Iranzo, A.
- Bassetti, C.
- Chen, W.M.
- Concannon, P.
- Thompson, S.D.
- Damotte, V.
- Fontaine, B.
- Breban, M.
- Gieger, C.
- Klopp, N.
- Deloukas, P.
- Wijmenga, C.
- Hallmayer, J.
- Onengut-Gumuscu, S.
- Rich, S.S.
- Winkelmann, J.
- Mignot, E.
DOIAbstract
Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome 6 were significantly associated with disease risk. In addition to a strong signal in the T cell receptor alpha (TRA@), variants in two additional narcolepsy loci, Cathepsin H () and Tumor necrosis factor (ligand) superfamily member 4 (, also ...
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