Relapse and graft-versus-host disease remain major problems associated with allogeneic bone marrow (BM) transplantation (allo-BMT) and posttransplantation therapy in patients with multiple myeloma (MM) and other hematologic malignancies. A possible strategy for selectively enhancing the graft-versus-myeloma response and possibly reducing graft-versus-host disease is to increase the migration of alloreactive T cells toward the MM-containing BM. In the present study, we characterized the BM-homing behavior of donor-derived effector T cells in a novel allo-BMT model for the treatment of MM. We observed that posttransplantation immunotherapy consisting of donor lymphocyte infusion (DLI) and vaccination with minor histocompatibility antigen-load...
AbstractWe reported previously that anti-CD3 mAb treatment before hematopoietic cell transplantation...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
Allogeneic stem cell transplantation (SCT) in multiple myeloma (MM) may induce a curative graft-vers...
AbstractRelapse and graft-versus-host disease remain major problems associated with allogeneic bone ...
Transplantation with autologous hematopoietic progenitors remains an important consolidation treatme...
AbstractDelayed immunologic recovery after allogeneic bone marrow transplantation (BMT) represents a...
Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recu...
AbstractMyeloid-derived suppressor cells (MDSCs) are a group of myeloid cells composed of hematopoie...
Background: Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival a...
The graft-versus-myeloma (GVM) effect represents a powerful form of immune attack exerted by allorea...
Recently, we demonstrated that reduced intensity conditioning (RIC) followed by partial T-cell-deple...
The graft-versus-myeloma (GVM) effect represents a powerful form of immune attack exerted by allorea...
Immune reconstitution after conventional allogeneic transplantation is a major determinant of surviv...
Allogeneic stem cell transplantation (SCT) in multiple myeloma (MM) may induce a curative graft-vers...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
AbstractWe reported previously that anti-CD3 mAb treatment before hematopoietic cell transplantation...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
Allogeneic stem cell transplantation (SCT) in multiple myeloma (MM) may induce a curative graft-vers...
AbstractRelapse and graft-versus-host disease remain major problems associated with allogeneic bone ...
Transplantation with autologous hematopoietic progenitors remains an important consolidation treatme...
AbstractDelayed immunologic recovery after allogeneic bone marrow transplantation (BMT) represents a...
Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recu...
AbstractMyeloid-derived suppressor cells (MDSCs) are a group of myeloid cells composed of hematopoie...
Background: Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival a...
The graft-versus-myeloma (GVM) effect represents a powerful form of immune attack exerted by allorea...
Recently, we demonstrated that reduced intensity conditioning (RIC) followed by partial T-cell-deple...
The graft-versus-myeloma (GVM) effect represents a powerful form of immune attack exerted by allorea...
Immune reconstitution after conventional allogeneic transplantation is a major determinant of surviv...
Allogeneic stem cell transplantation (SCT) in multiple myeloma (MM) may induce a curative graft-vers...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
AbstractWe reported previously that anti-CD3 mAb treatment before hematopoietic cell transplantation...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
Allogeneic stem cell transplantation (SCT) in multiple myeloma (MM) may induce a curative graft-vers...