Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles
- Linden, J.W.M. van der
- Camps, S.M.T.
- Kampinga, G.A.
- Arends, J.P.
- Debets-Ossenkopp, Y.J.
- Haas, P.J.
- Rijnders, B.J.
- Kuijper, E.J.
- Tiel, F.H. van
- Varga, J.
- Karawajczyk, A.
- Zoll, J.
- Melchers, W.J.G.
- Verweij, P.E.
DOIAbstract
BACKGROUND: Azole resistance is an emerging problem in Aspergillus fumigatus and complicates the management of patients with Aspergillus-related diseases. Selection of azole resistance may occur through exposure to azole fungicides in the environment. In the Netherlands a surveillance network was used to investigate the epidemiology of resistance selection in A. fumigatus. METHODS: Clinical A. fumigatus isolates were screened for azole resistance in 8 university hospitals using azole agar dilution plates. Patient information was collected using an online questionnaire and azole-resistant A. fumigatus isolates were analyzed using gene sequencing, susceptibility testing, and genotyping. Air sampling was performed to investigate the presence o...
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