During chronic kidney disease (CKD), drug metabolism is affected leading to changes in drug disposition. Furthermore, there is a progressive accumulation of uremic retention solutes due to impaired renal clearance. Here, we investigated whether uremic toxins can influence the metabolic functionality of human conditionally immortalized renal proximal tubule epithelial cells (ciPTEC) with the focus on UDP-glucuronosyltransferases (UGTs) and mitochondrial activity. Our results showed that ciPTEC express a wide variety of metabolic enzymes, including UGTs. These enzymes were functionally active as demonstrated by the glucuronidation of 7-hydroxycoumarin (7-OHC; K(m) of 12+/-2muM and a V(max) of 76+/-3pmol/min/mg) and p-cresol (K(m) of 33+/-13mu...
BACKGROUND: Chronic kidney disease (CKD) is characterized by the progressive accumulation of various...
A host of compounds are retained in the body of uremic patients, as a consequence of progressive ren...
Purpose of ReviewChronic kidney disease (CKD) is characterized by the accumulation of uremic retenti...
AbstractDuring chronic kidney disease (CKD), drug metabolism is affected leading to changes in drug ...
Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult population i...
Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult population i...
Because kidneys consume a large amount of oxygen and are relatively inefficient in oxygen uptake, th...
Contains fulltext : 154383.pdf (publisher's version ) (Open Access)In renal failur...
In patients with chronic kidney disease (CKD), adequate renal clearance is compromised, resulting in...
In patients with severe kidney disease, renal clearance is compromised, resulting in the accumulatio...
Several organic cations, such as guanidino compounds and polyamines, have been found to accumulate i...
Chronic kidney disease (CKD) is characterized by the progressive accumulation of various potential t...
Background and aims Chronic kidney disease (CKD) in children is an irreversible process that may lea...
Kidney diseases encompass many pathologies, including obstructive nephropathy (ON), a common clinica...
In renal failure, the systemic accumulation of uremic waste products is strongly associated with the...
BACKGROUND: Chronic kidney disease (CKD) is characterized by the progressive accumulation of various...
A host of compounds are retained in the body of uremic patients, as a consequence of progressive ren...
Purpose of ReviewChronic kidney disease (CKD) is characterized by the accumulation of uremic retenti...
AbstractDuring chronic kidney disease (CKD), drug metabolism is affected leading to changes in drug ...
Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult population i...
Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult population i...
Because kidneys consume a large amount of oxygen and are relatively inefficient in oxygen uptake, th...
Contains fulltext : 154383.pdf (publisher's version ) (Open Access)In renal failur...
In patients with chronic kidney disease (CKD), adequate renal clearance is compromised, resulting in...
In patients with severe kidney disease, renal clearance is compromised, resulting in the accumulatio...
Several organic cations, such as guanidino compounds and polyamines, have been found to accumulate i...
Chronic kidney disease (CKD) is characterized by the progressive accumulation of various potential t...
Background and aims Chronic kidney disease (CKD) in children is an irreversible process that may lea...
Kidney diseases encompass many pathologies, including obstructive nephropathy (ON), a common clinica...
In renal failure, the systemic accumulation of uremic waste products is strongly associated with the...
BACKGROUND: Chronic kidney disease (CKD) is characterized by the progressive accumulation of various...
A host of compounds are retained in the body of uremic patients, as a consequence of progressive ren...
Purpose of ReviewChronic kidney disease (CKD) is characterized by the accumulation of uremic retenti...